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Sedative action CBD effects on anxiety psychoses and movement disorders (1980’s and 1990’s) After the peak of reports on CBD in the 1970’s the next two decades the publication rate remained stabilized indicating a lower degree of interest on the study of therapeutic actions of CBD. The reports in this field were maintained mainly by Brazilian researchers investigating the anxiolytic and antipsychotic properties of CBD and by a few studies about its effects in cbd hair motor diseases conducted by Cannabinoid Means Consroe et al.4849 1. Anxiolytic action In 1974 an interactive study between CBD and THC per os in healthy volunteers gave the first clue that benefits of the cbd in kenya CBD could act as an anxiolytic drug.22 This study showed that CBD (60 mg) added to Cannabinoid Means delta9-THC (30 mg) changed the symptoms is cbd legal in south africa
induced by delta9-THC alone in such a way that the subjects receiving the mixture showed less anxiety and more pleasurable effects. In 1982 a study with appropriate rating scales confirmed that CBD (1 mg/kg) co-administered with delta9-THC (0.5 mg/kg) significantly reduced anxiety indexes in healthy volunteers.46 The anxiolytic properties of CBD have been demonstrated by several pre-clinical studies that employed different paradigms such as the conditioned emotional response50 the Vogel conflict test51 and the elevated plus-maze.5253 In the latter study53 the effective doses of CBD ranged from 2.5 to 10 mg/kg and hemp oil legal uk the drug produced an inverted U-shaped dose-response curve the higher doses being no longer effective. This could explain the negative results obtained with high doses of CBD (above 100 mg/kg) in a previous study employing the Geller-Seifter conflict test.54 A recent study showed that the anxiolytic effect of CBD in the Vogel test was not mediated by benzodiazepine receptors.55 Cannabinoid Means 2. Antipsychotic action The first evidence that CBD could have antipsychotic effects was obtained in the interactive study of CBD and delta9-THC in healthy volunteers published in 1982.
These lines of evidence led to several investigations of a possible antipsychotic action of CBD. As a first step to investigate antipsychotic-like properties of CBD in animal models the drug was compared to haloperidol in rats.60 Both drugs reduced the apomorphine-induced stereotyped behavior (such as sniffing and biting) in a dose-related manner. Even though these drugs also increased the plasma level of prolactine CBD needs higher doses (120 and 240 mg/kg) to show such an effect.