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CBD: p > 0.65). Experiment 4 determined that when 200mg CBD was vaporised almost 82mg CBD (41%) was delivered into the balloon on average but there was significant variability (large standard errors). In Experiment 6 the combination of 8mg THC with 200mg CBD when vaporised resulted in reduced delivery of each compound into the balloon relative to when each was vaporised alone: 4.
Further using our data reported above in order to compare the effects of loaded doses of 8mg THC and 400mg CBD in combination with the effects of each compound separately we opted to load the vaporiser with 8mg THC and 200mg CBD for delivery into the first balloon (vaporised side effects from quitting smoking pot to deliver approximately 4.4mg THC and 74mg CBD) and we loaded 4mg THC and 200mg CBD for delivery into the second balloon (vaporised to deliver 2.2mg THC and 78mg cbd legality CBD). The total doses delivered from these two balloons equal 6.6mg THC and 152mg CBD; this achieved equivalence broadly with the 6.2mg THC and 163mg CBD delivered when each compound was delivered separately. Alternatively THC and CBD could be loaded and vaporised separately into two balloons that the participant inhales sequentially but this could result in quite different pharmacokinetic and pharmacodynamic effects compared to simultaneous administration of the two compounds and the methodology depends upon the questions to be addressed in the research. Conclusions Many questions arise regarding additive synergistic and interactive effects of THC and CBD and the field is ripe for the further investigation of these intriguing compounds. The methods protocols and preliminary data presented here established the optimal efficiency of delivery of both low and high doses of CBD alone and in combination with THC by vaporisation. While intrapulmonary administration generally results in high systemic bioavailability the extent of absorption of the high doses of CBD Cbd Oil Glioblastoma that we were able to achieve relative to oral doses of 600mg remains to be determined as do their potential therapeutic effects. The studies informed the development of methods for a randomised controlled trial of simultaneous acute administration of these hash oil cartridges for e cig cannabinoids by vaporisation to human research participants in our laboratory 18 and may assist researchers with designing their own future clinical trials and experimental human studiesa.