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The possible neuroprotective actions of CBD highlight the importance of studies on the therapeutic potential of this compound in Alzheimer’s disease (AD). AD is widely associated with oxidative stress due in part to the membrane action of beta-amyloid peptide (beta-A) aggregates. A marked reduction in the cell survival was observed following exposure of cultured rat pheochromocytoma PC12 cells to beta-A peptide. Treatment of the cells with CBD prior to beta-A exposure significantly elevated the cell survival probably by a combination of neuroprotective anti-oxidative and anti-apoptotic actions against beta-A toxicity –
- I think if we get a stronger oil the water in her legs will stay down permanently
- This research was supported by the National Eye Institute a division of the federal National Institutes of Health
- Journal of Abnormal Psychology 112(3): 393-402 Anne Harding: Pot-induced psychosis may signal schizophrenia Reuters 3
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. In addition CBD cbd in hemp oil inhibited caspase 3 generation from its inactive precursor pro-caspase 3 an effect that is involved in the signaling pathway for this neuroprotection.80 In the search for the molecular mechanism of this CBD-induced Organic Hemp Seed Oil Eczema neuroprotective action it was reported that CBD inhibits hyperphosphorylation of tau protein in beta-A-stimulated PC12 neuronal cells which is one of the most representative hallmarks of AD.81 A possible anti-inflammatory action may be involved in this CBD effect since CBD inhibited both nitrite production and nitric oxide synthase (iNOS) protein expression induced by beta-A.82 These results of in vitro studies were confirmed in vivo with a mouse model of AD-related cbd oil legal in indiana neuroinflammation. Mice were inoculated with human beta-A into the right dorsal hippocampus and treated daily with vehicle or CBD (2.5 or 10 mg kg i.p.) for 7 days. cbd immune system
In contrast to vehicle CBD dose-dependent significantly inhibited mRNA for glial fibrillary acidic protein and the protein expression in beta-A injected Organic Hemp Seed Oil Eczema animals.