By reducing arrestin2 recruitment to CB1 receptors cannabidiol treatment prevented internalization of these receptors. The allosteric activity of cannabidiol depended upon polar residues being present at positions 98 and 107 in the extracellular amino terminus of the CB1 receptor. Conclusions and Implications Cannabidiol behaved as a non-competitive negative allosteric modulator of CB1 receptors.
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To Tincture Cbd Brands confirm the time-dependent CBD-induced increase in apoptosis in MDA-MB-231 cells we quantified Annexin V positivity under conditions identical to that used for the Western blot analysis. Consistent with the data attained by Western blotting we observed a significant increase in Annexin V-positive MDA-MB-231 cells 16 and 24 hours after CBD treatment ( Fig. 3B ).
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Cultures were grown in either serum-free medium alone (control)
or in a medium containing 10 ?M or 25 ?M CBD. After 24 h of exposure cells were detached centrifuged resuspended and incubated with PI solution and apoptosis was quantified as reduced fluorescence by flow cytometry on the total cell population (adhering + detached cells). A representative experiment is shown in the figure.
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