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The conclusion was that the antioxidant properties of CBD can provide neuroprotection against the progressive degeneration of nigrostriatal dopaminergic neurons that occur in PD.76 This is reinforced by the observation that CBD reduced the striatal atrophy caused by 3-nitropropionic acid in vivo through mechanisms independent of the activation of cannabinoid vanilloid TRPV1 and adenosine A2A receptors.77 The neuroprotective action of CBD in the human basal ganglia was suggested by the strong positive correlation of N-acetylaspartate/total creatine ratio and CBD in the putamen/globus pallidum found in recreational cannabis users. Where To Buy best cbd e liquid uk Cannabidiol Oil In Nj this could reflect an enhancement of neuronal and axonal integrity in these regions by CBD.78 Considering the relevance of these preclinical data and the possible antipsychotic effect of CBD a recently study Where To Buy Cannabidiol Oil In Nj evaluated for the first time the efficacy tolerability and safety of CBD in PD patients with psychotic symptoms.79 In an open-label pilot study six consecutive outpatients with the diagnosis of PD and who also had psychosis for at least 3 months have received a flexible-dose regimen of CBD administration (starting with an oral dose of 150 mg/day) for four weeks in addition to their usual therapy. The psychotic symptoms significantly decreased along the CBD treatment and the scale used to follow up the PD course exhibited a significant decrease of the total score. These preliminary data suggest that CBD may have a beneficial action in PD.79 The possible neuroprotective actions of Where To Buy Cannabidiol Oil In Nj CBD highlight the importance of studies on the therapeutic potential of this compound in Alzheimer’s disease (AD). AD is widely associated with oxidative stress due in part to the membrane action of beta-amyloid peptide (beta-A) aggregates. A marked reduction in the cell survival was observed following exposure of cultured rat pheochromocytoma PC12 cells to beta-A peptide.

THC alters neurotransmitter release in the spinal cord resulting in pain relief. The compound is also known to stimulate appetite (informally known as “the munchies”) and induce a relaxed state as well has having effects on the person’s sense of smell hearing and eyesight. THC can also cause fatigue In some people THC may reduce symptoms of aggression. Some limited studies have shown that THC shows promise for the treatment of nausea and vomiting – it may have antiemetic qualities that make it helpful as an adjunct therapy for people undergoing chemotherapy or other treatment where nausea can be a side effect.

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Kolja Schumann: Das Kiffer-Lexikon. Das alternative ABC der Hanfkultur. Nachtschatten Verlag Solothurn 2004 ISBN 3-03788-122-4 Bernhard van Treeck: Das gro├če Cannabis-Lexikon. Schwarzkopf & Schwarzkopf Berlin 2000 ISBN 3-89602-268-7 Bernd Werse: Cannabis in Jugendkulturen.

Self-reported cannabis use as a risk factor for schizophrenia in Swedish conscripts of 1969: Historical cohort study. British Medical Journal 2002. 325: p.

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The anti-oxidative action of CBD can be responsible for the neuroprotection reported in animal models of Parkinson’s disease (PD). Daily administration of CBD during 2 weeks may produce a significant waning in the magnitude of toxic effects caused by a unilateral injection of 6-hydroxydopamine into the medial Where To Buy Cannabidiol Oil In Nj forebrain bundle75 probably due to receptor-independent actions. In this model of PD CBD led to an up-regulation of mRNA levels of Cu/Zn-superoxide dismutase a key enzyme in endogenous defense against oxidative stress. The conclusion was that the antioxidant properties of CBD can provide neuroprotection against the progressive degeneration of nigrostriatal dopaminergic neurons that occur in PD.

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